STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2
STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2
Liting Zhang,Congqing Jiang,18 Authors,Junjie Zhang
2023 · DOI: 10.1038/s41556-023-01185-x
Nature Cell Biology · 90 Citations
TLDR
It is reported that STING restricts aerobic glycolysis independent of its innate immune function, and this findings have important implications for the development of STING-based therapeutic modalities to improve antitumour immunotherapy.