SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70
SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70
N. Sundaresan,S. Samant,2 Authors,Mahesh P. Gupta
2008 · DOI: 10.1128/MCB.00426-08
Molecular and Cellular Biology · 546 Citations
TLDR
It is found that SIRT3 is a stress-responsive deacetylase and that its increased expression protects myocytes from genotoxic and oxidative stress-mediated cell death, and identifies Ku70 as a new target of Sirt3.