Roles of TRPA1 and TRPV1 in cigarette smoke -induced airway epithelial cell injury model.
Roles of TRPA1 and TRPV1 in cigarette smoke -induced airway epithelial cell injury model.
Muyun Wang,Yanbei Zhang,5 Authors,Feng Li
2019 · DOI: 10.1016/j.freeradbiomed.2019.01.004
Free Radical Biology & Medicine · 137 Citations
TLDR
Both TRPA1 and TRPV1 mediate CSE-induced damage of bronchial and alveolar epithelial cells via modulation of oxidative stress, inflammation and mitochondrial damage and their inhibition should be considered as potential therapy for COPD.