Role of GPR81 in lactate-mediated reduction of adipose lipolysis.
Role of GPR81 in lactate-mediated reduction of adipose lipolysis.
T. Cai,N. Ren,6 Authors,M. Waters
2008 · DOI: 10.1016/j.bbrc.2008.10.088
Biochemical and Biophysical Research Communications - BBRC · 264 Citations
TLDR
Pharmacological and genetic approaches are employed to show that GPR81, an orphan G-protein-coupled receptor with relatively restricted expression in the adipose tissues, functions as a receptor for lactate and can mediate an anti-lipolytic effect of lactate.