Role of CaV&bgr; Subunits, and Lack of Functional Reserve, in Protein Kinase A Modulation of Cardiac CaV1.2 Channels
Role of CaV&bgr; Subunits, and Lack of Functional Reserve, in Protein Kinase A Modulation of Cardiac CaV1.2 Channels
Jayalakshmi Miriyala,Trang X Nguyen,D. T. Yue,H. Colecraft
2008 · DOI: 10.1161/CIRCRESAHA.108.171736
Circulation Research · 60 Citations
TLDR
Overexpression of all CaV channel subunits is used to simultaneously identify the impact of auxiliary CaV&bgr;s on PKA modulation of ICa,L and gauge the functional reserve of this regulation in the heart, uncovering a new design principle of this phenomenon in theheart, vis à vis a limited functional reserve.