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Residue burial encodes a protein’s fold

Alex T. Grigas,Jacob Sumner,Corey S. O'Hern

2026 · DOI: 10.64898/2026.03.28.714986
bioRxiv · 0 Citations

TLDR

It is found that residue core identity, a binary N-dimensional encoding indicating whether each of the N amino acids in a protein is buried in the core or not, can predict the protein’s backbone conformation more efficiently than all other representations that were tested.