Regulation of HMG‐CoA reductase: identification of the site phosphorylated by the AMP‐activated protein kinase in vitro and in intact rat liver.
Regulation of HMG‐CoA reductase: identification of the site phosphorylated by the AMP‐activated protein kinase in vitro and in intact rat liver.
P. Clarke,D. Hardie
1990 · DOI: 10.1002/j.1460-2075.1990.tb07420.x
EMBO Journal · 310 Citations
TLDR
Phosphopeptide mapping of native, 100 kd microsomal HMG‐CoA reductase confirms that this C‐terminal serine is the only major site phosphorylated in the intact enzyme by the AMP‐activated protein kinase.