Rab5a is a common component of the apical and basolateral endocytic machinery in polarized epithelial cells.
Rab5a is a common component of the apical and basolateral endocytic machinery in polarized epithelial cells.
Cecilia Bucci,Angela Wandinger-Ness,3 Authors,Marino Zerial
1994 · DOI: 10.1073/PNAS.91.11.5061
Proceedings of the National Academy of Sciences of the United States of America · 113 Citations
TLDR
The data indicate that the apical and basolateral endocytic machineries of epithelial cells share common regulatory components and that Rab5a per se is not sufficient to target endocytical vesicles to apical or Basolateral early endosomes.