RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells
RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells
Stephanie L. Sanos,Viet L Bui,4 Authors,A. Diefenbach
2009 · DOI: 10.1038/ni.1684
Nature Immunology · 859 Citations
TLDR
Evidence is provided that signals from the commensal microflora contribute to the differentiation of a lymphocyte population coexpressing stimulatory natural killer cell receptors and the transcription factor RORγt that produced interleukin 22 (IL-22).