RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS
RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS
Yasushi Ito,D. Ofengeim,18 Authors,Junying Yuan
2016 · DOI: 10.1126/science.aaf6803
Science · 508 Citations
TLDR
It is found that optineurin actively suppressed receptor-interacting kinase 1 (RIPK1)–dependent signaling by regulating its turnover, and inhibiting RIPK1 kinase may provide an axonal protective strategy for the treatment of ALS and other human degenerative diseases characterized by axonal degeneration.