RAL-1 controls multivesicular body biogenesis and exosome secretion
RAL-1 controls multivesicular body biogenesis and exosome secretion
Vincent Hyenne,Ahmet Apaydin,8 Authors,Michel Labouesse
2015 · DOI: 10.1083/jcb.201504136
Journal of Cell Biology · 66 Citations
Abstract
In Caenorhabditis elegans, the RAL-1 GTPase regulates multivesicular body formation and fusion with the plasma membrane, thereby promoting exosome secretion; in mammals, RalA and RalB are required for the secretion of exosome-like vesicles.