RAG-1-deficient mice have no mature B and T lymphocytes.
RAG-1-deficient mice have no mature B and T lymphocytes.
P. Mombaerts,J. Iacomini,3 Authors,V. Papaioannou
1992 · DOI: 10.1016/0092-8674(92)90030-G
Cell · 3,039 Citations
TLDR
The introduction of a mutation in RAG-1 into the germline of mice via gene targeting in embryonic stem cells is described and it is shown that this mutation either activates or catalyzes the V(D)J recombination reaction of immunoglobulin and T cell receptor genes.