Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signaling.
Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signaling.
Krista M. Heinonen,N. Dubé,2 Authors,M. Tremblay
2006 · DOI: 10.1073/PNAS.0508563103
Proceedings of the National Academy of Sciences of the United States of America · 79 Citations
TLDR
The results presented here show that the absence of PTP-1B affects murine myelopoiesis by modifying the ratio of monocytes to granulocytes in vivo and provide a demonstration of a physiological role for PTP,1B in immune regulation.