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Prospective randomized double‐blind comparative study of topical acetyl zingerone with tetrahexyldecyl ascorbate versus tetrahexyldecyl ascorbate alone on facial photoaging

N. Afzal,Nhi Nguyen,5 Authors,Raja K. Sivamani

2024 · DOI: 10.1111/jocd.16292
Journal of Cosmetic Dermatology · 4 Citations

TLDR

Tetrahexydecyl ascorbate is a lipophilic precursor to ascorbic acid that may be stabilized by acetyl zingerone, and has been shown to mitigate oxidative and inflammatory stress, thereby improving the appearance of photoaging.

Abstract

Tetrahexydecyl ascorbate (THDA) is a lipophilic precursor to ascorbic acid that may be stabilized by acetyl zingerone (AZ). Studies have shown that the topical application of THDA may have photoprotective effects. Similarly, AZ has been shown to mitigate oxidative and inflammatory stress, thereby improving the appearance of photoaging.