Preventive effects of two PAF-antagonists, PMS 536 and PMS 549, on cyclosporin-induced LLC-PK1 oxidative injury.
Preventive effects of two PAF-antagonists, PMS 536 and PMS 549, on cyclosporin-induced LLC-PK1 oxidative injury.
F. Massicot,A. Lamouri,5 Authors,J. Claude
1997 · DOI: 10.1016/S0929-7855(96)00555-X
Journal of Lipid Mediators and Cell Signalling · 18 Citations
TLDR
The results suggest that both PAF antagonists attenuate CsA oxidative injury and prevent energy metabolism disturbances probably by maintaining cell integrity and the lipophilicity of both molecules may be responsible for membrane stabilization and may confer the protective effects observed in energy metabolism.