Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome
Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome
S. Schoenfelder,R. Sugar,19 Authors,Sarah Elderkin
2015 · DOI: 10.1038/ng.3393
Nature Genetics · 352 Citations
TLDR
PRC1 physically constrains developmental transcription factor genes and their enhancers in a silenced but poised spatial network and it is proposed that the selective release of genes from this spatial network underlies cell fate specification during early embryonic development.