Platycodin D and D3 isolated from the root of Platycodon grandiflorum modulate the production of nitric oxide and secretion of TNF-alpha in activated RAW 264.7 cells.
Platycodin D and D3 isolated from the root of Platycodon grandiflorum modulate the production of nitric oxide and secretion of TNF-alpha in activated RAW 264.7 cells.
Chuanhua Wang,Georgia B Schuller Levis,5 Authors,E. Park
2004 · DOI: 10.1016/J.INTIMP.2004.04.005
International Immunopharmacology · 135 Citations
TLDR
A dichotomous regulation of these important proinflammatory mediators by PD and PD3 is suggested, suggesting that PD may stimulate TNF-alpha synthesis or inhibit degradation of T NF-alpha mRNA.