PRDX6 dictates ferroptosis sensitivity by directing cellular selenium mobilization
PRDX6 dictates ferroptosis sensitivity by directing cellular selenium mobilization
Junya Ito,Toshitaka Nakamura,12 Authors,M. Conrad
2024 · DOI: 10.1101/2024.06.04.595693
bioRxiv · 0 Citations
TLDR
This study highlights PRDX6 as a critical factor in ferroptosis prevention by directing cellular selenium mobilization by facilitating intracellular selenium handling, which is crucial for selenium incorporation into selenoproteins, including GPX4.