PO-614-04 STABILIZING CARDIAC RYANODINE RECEPTOR WITH DANTROLENE PREVENTS BINGE ALCOHOL AND CAFFEINE INDUCED VENTRICULAR TACHYARRHYTHMIAS

The data suggests loss of t-tubules, decreased Ca release at triggered and propagated sites and RyR cluster remodelling all contribute to the decrease in the atrial systolic Ca transient and dyssynchrony observed in HF.