PDE3A mutations cause autosomal dominant hypertension with brachydactyly

It is suggested that the identified PDE3A mutations cause mendelian hypertension, a syndrome that features brachydactyly type E, severe salt-independent but age-dependent hypertension, an increased fibroblast growth rate, neurovascular contact at the rostral-ventrolateral medulla, altered baroreflex blood pressure regulation and death from stroke before age 50 years when untreated.