PD12-08 A RADIATION-FREE, VIRTUAL MEASUREMENT OF MOUSE BLADDER BLOOD FLOW
Pradeep Tyagi,Anirban Ganguly,4 Authors,Travis Nguyen
TLDR
This is the first reliable measurement of mouse bladder perfusion in a radiation-free and non-tissue destructive fashion and a method amenable to repeated measurment on same animal for quantifying the impact of outlet obstruction, infection, or in fl ammation and treatment on bladder blood.
Abstract
of respective time-intensity curves. Tofts modelling of DCE computed that injected Gadobutrol [30 mM] gets instantly diluted 15 fold and 75 fold to > 2 mM and 0.4 mM in artery and BW, respectively. While > 2 mM indexes the arterial input function of internal iliac artery with a reported blood fl ow rate of w 2 mL/min (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348007/), the ratio of 0.4:2 mM indexes that the relative bladder blood fl ow is 25% of iliac artery, or 0.4 mL/min. CONCLUSIONS: This is a fi rst reliable measurement of mouse bladder perfusion in a radiation-free and non-tissue destructive fashion, a method amenable to repeated measurment on same animal for quantifying the impact of outlet obstruction, infection, or in fl ammation and treatment on bladder blood fl ow.