PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
C. Day,D. Kaufmann,19 Authors,Bruce D. Walker
2006 · DOI: 10.1038/nature05115
Nature · 2,862 Citations
TLDR
The data indicate that the immunoregulatory PD-1/PD-L1 pathway is operative during a persistent viral infection in humans, and define a reversible defect in HIV-specific T-cell function.