P2X7 receptor antagonist BBG inhibits endoplasmic reticulum stress and pyroptosis to alleviate postherpetic neuralgia
P2X7 receptor antagonist BBG inhibits endoplasmic reticulum stress and pyroptosis to alleviate postherpetic neuralgia
Yuyou Zhu,Siping Zhang,Yuanbo Wu,Juan Wang
2021 · DOI: 10.1007/s11010-021-04169-3
Molecular and Cellular Biochemistry · 15 Citations
TLDR
P2X7 receptor antagonist BBG alleviates PHN by activating ER stress and reducing pyroptosis and, in addition, ER stress activator tunicamycin (TM) can reverse the effect of BBG on the paw withdrawal thresholds, endoplasmic reticulum stress, and pyroPTosis.