Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Aβ levels
Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Aβ levels
Ana-María Simón,L. Schiapparelli,6 Authors,D. Frechilla
2009 · DOI: 10.1016/j.nbd.2008.11.005
Neurobiology of Disease · 107 Citations
TLDR
The results support the notion of Abeta-independent pathogenic pathways in Alzheimer's disease and exclude mutant mice expressing mutant hAPP.