Ockham's razor and selective androgen receptor modulators (SARMs): are we overlooking the role of 5alpha-reductase?
Ockham's razor and selective androgen receptor modulators (SARMs): are we overlooking the role of 5alpha-reductase?
Wenqing Gao,J. Dalton
2007 · DOI: 10.1124/MI.7.1.3
Molecular Interventions · 42 Citations
TLDR
The tissue-specific expression of 5alpha-reductase might provide a simple explanation for this puzzle of the SARM story, and lead compounds with much improved specificity for AR, in vivo pharmacokinetic profiles, and higher degree of tissue selectivity have entered clinical development.