Novel role of the nutraceutical bioactive compound berberine in lectin-like OxLDL receptor 1-mediated endothelial dysfunction in comparison to lovastatin.
Novel role of the nutraceutical bioactive compound berberine in lectin-like OxLDL receptor 1-mediated endothelial dysfunction in comparison to lovastatin.
C. Caliceti,P. Rizzo,12 Authors,A. Cicero
2017 · DOI: 10.1016/j.numecd.2017.04.002
NMCD. Nutrition Metabolism and Cardiovascular Diseases · 33 Citations
TLDR
It is demonstrated for the first time that BBR could prevent the oxLDL and TNFα - induced LOX1 expression and oxidative stress, key events that lead to NOX, MAPK/Erk1/2 and NF-κB activation linked to endothelial dysfunction.