Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.
B. Oppmann,R. Lesley,22 Authors,R. Kastelein
2000 · DOI: 10.1016/S1074-7613(00)00070-4
Immunity · 3,004 Citations
TLDR
Human IL-23 stimulates IFN-gamma production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells and induces strong proliferation of mouse memory T cells.