Nonsteroidal Anti‐inflammatory Use and LRRK2 Parkinson's Disease Penetrance
Nonsteroidal Anti‐inflammatory Use and LRRK2 Parkinson's Disease Penetrance
M. San Luciano,C. Tanner,21 Authors,R. Saunders-Pullman
2020 · DOI: 10.1002/mds.28189
Movement Disorders · 76 Citations
TLDR
Nonsteroidal anti‐inflammatory drugs (NSAIDs) are known to reduce inflammation and may lower Parkinson's disease (PD) risk, but their role in LRRK2‐associated PD is unknown.
Abstract
The penetrance of leucine rich repeat kinase 2 (LRRK2) mutations is incomplete and may be influenced by environmental and/or other genetic factors. Nonsteroidal anti‐inflammatory drugs (NSAIDs) are known to reduce inflammation and may lower Parkinson's disease (PD) risk, but their role in LRRK2‐associated PD is unknown.