Noninvasive prenatal detection and selective analysis of cell-free DNA obtained from maternal blood: evaluation for trisomy 21 and trisomy 18.
Noninvasive prenatal detection and selective analysis of cell-free DNA obtained from maternal blood: evaluation for trisomy 21 and trisomy 18.
A. Sparks,C. Struble,2 Authors,A. Oliphant
2012 · DOI: 10.1016/j.ajog.2012.01.030
American Journal of Obstetrics and Gynecology · 427 Citations
TLDR
Digital analysis of selected regions and FORTE enable accurate, scalable noninvasive fetal aneuploidy detection and produce an individualized trisomy risk score for each subject.