Niclosamide induces miR-148a to inhibit PXR and sensitize colon cancer stem cells to chemotherapy
Niclosamide induces miR-148a to inhibit PXR and sensitize colon cancer stem cells to chemotherapy
Lucile Bansard,Océane Bouvet,12 Authors,C. Planque
2022 · DOI: 10.1016/j.stemcr.2022.02.005
Stem Cell Reports · 24 Citations
TLDR
The study suggests that endogenous miRNA inducers is a viable strategy to down-regulate PXR and illuminates niclosamide as a neoadjuvant repurposing strategy to prevent tumor relapse in colon cancer.