Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice.
Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice.
C. Elson,Y. Cong,4 Authors,R. Kastelein
2007 · DOI: 10.1053/J.GASTRO.2007.03.104
Gastroenterology · 485 Citations
TLDR
Bacterial-reactive CD4(+) Th17 cells are potent effector cells in chronic colitis and IL-23 is an attractive therapeutic target for inflammatory bowel disease.