Monoacylglycerol lipase inhibitor JZL184 prevents HIV‐1 gp120‐induced synapse loss by altering endocannabinoid signaling
Monoacylglycerol lipase inhibitor JZL184 prevents HIV‐1 gp120‐induced synapse loss by altering endocannabinoid signaling
Xinwen Zhang,S. Thayer
2018 · DOI: 10.1016/j.neuropharm.2017.10.023
Neuropharmacology · 36 Citations
TLDR
MGL presents a promising target for preventing synapse loss in neuroinflammatory conditions such as HAND, and JZL184‐induced decreases in PGE2 levels may also protect synapses.