Molecular pathogenesis of inherited hypertension with hyperkalemia: The Na–Cl cotransporter is inhibited by wild-type but not mutant WNK4
Molecular pathogenesis of inherited hypertension with hyperkalemia: The Na–Cl cotransporter is inhibited by wild-type but not mutant WNK4
F. H. Wilson,K. Kahle,6 Authors,R. Lifton
2003 · DOI: 10.1073/pnas.242735399
Proceedings of the National Academy of Sciences of the United States of America · 408 Citations
TLDR
It is demonstrated that WNK4 negatively regulates surface expression of NCCT and implicate loss of this regulation in the molecular pathogenesis of an inherited form of hypertension.