Molecular chaperones and proteostasis regulation during redox imbalance☆
Molecular chaperones and proteostasis regulation during redox imbalance☆
K. Niforou,Christina Cheimonidou,I. Trougakos
2014 · DOI: 10.1016/j.redox.2014.01.017
Redox Biology · 224 Citations
TLDR
The expression and the activity of the molecular chaperones are tightly regulated at both the transcriptional and post-translational level at organismal states of increased oxidative and, consequently, proteotoxic stress, including ageing and various age-related diseases (e.g. degenerative diseases and cancer).