Modulation of TNF-α-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-α production and facilitates viral entry
Modulation of TNF-α-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-α production and facilitates viral entry
S. Haga,N. Yamamoto,6 Authors,Y. Ishizaka
2008 · DOI: 10.1073/pnas.0711241105
Proceedings of the National Academy of Sciences of the United States of America · 461 Citations
TLDR
It is found that the spike protein of SARS-CoV (SARS-S) induced TNF-α-converting enzyme (TACE)-dependent shedding of the ACE2 ectodomain, and this data suggest that cellular signals triggered by the interaction of Sars- coV with ACE2 are positively involved in viral entry but lead to tissue damage.