Mitochondrial Perturbations Couple mTORC2 to Autophagy in C. elegans.
Mitochondrial Perturbations Couple mTORC2 to Autophagy in C. elegans.
Helena Aspernig,Thomas Heimbucher,6 Authors,Antje Thien
2019 · DOI: 10.1016/j.celrep.2019.09.072
Cell Reports · 61 Citations
TLDR
It is shown that inactivation of mTORC2 and its direct target serum- and glucocorticoid-inducible kinase 1 (SGK-1) potently induces autophagy and the autophagic degradation of mitochondria in C. elegans.