Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis.
Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis.
M. Zaman,Linda M. Trapani,6 Authors,P. Matsudaira
2006 · DOI: 10.1073/PNAS.0604460103
Proceedings of the National Academy of Sciences of the United States of America · 1,215 Citations
TLDR
The experimental findings here represent, to the knowledge, discovery of a previously undescribed set of balances of cell and matrix properties that govern the ability of tumor cells to migration in 3D environments.