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Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion

M. Byndloss,Erin E. Olsan,16 Authors,A. Bäumler

2017 · DOI: 10.1126/science.aam9949
Science · 958 Citations

TLDR

Microbiota-activated PPAR-γ signaling is a homeostatic pathway that prevents a dysbiotic expansion of potentially pathogenic Escherichia and Salmonella by reducing the bioavailability of respiratory electron acceptors to Enterobacteriaceae in the lumen of the colon.