Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor–Dependent Repression of Claudin-2
Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor–Dependent Repression of Claudin-2
Leon Zheng,Caleb J. Kelly,7 Authors,S. Colgan
2017 · DOI: 10.4049/jimmunol.1700105
Journal of Immunology · 460 Citations
TLDR
These findings provide a novel mechanism by which microbial-derived butyrate promotes barrier through IL-10RA–dependent repression of claudin-2 and enhance IEC barrier formation through activated Stat3 and HDAC inhibition.