Methylphenidate Increases Cortical Excitability via Activation of Alpha-2 Noradrenergic Receptors
Methylphenidate Increases Cortical Excitability via Activation of Alpha-2 Noradrenergic Receptors
Glenn D. Andrews,A. Lavin
2006 · DOI: 10.1038/sj.npp.1300818
Neuropsychopharmacology · 103 Citations
TLDR
It is proposed that methylphenidate is acting to increase catecholaminergic tone in the PFC, and thereby increases cortical excitability by mediating the disinhibition of pyramidal cells through mechanisms that may include activation of alpha-2 adrenoreceptors located in interneurons.