Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport.
Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport.
Chao‐ling Yang,Xiaoman Zhu,2 Authors,D. Ellison
2005 · DOI: 10.1172/JCI22452
Journal of Clinical Investigation · 174 Citations
TLDR
Insight is provided into the complex interrelationships between WNK1 and WNK4 and provide a molecular basis for familial hyperkalemic hypertension (FHHt), which is suggested to converge on a final common pathway.