Macrophage Migration Inhibitory Factor as a Chaperone Inhibiting Accumulation of Misfolded SOD1
Macrophage Migration Inhibitory Factor as a Chaperone Inhibiting Accumulation of Misfolded SOD1
A. Israelson,D. Ditsworth,15 Authors,D. Cleveland
2015 · DOI: 10.1016/j.neuron.2015.02.034
Neuron · 106 Citations
TLDR
Accumulated MIF protein is identified to be low in motor neurons, implicating correspondingly low chaperone activity as a component of vulnerability to mutant SOD1 misfolding and supporting therapies to enhance intracellular MIF chaper one activity.