MGST1, a new soldier of NRF2 in the battle against ferroptotic death.
MGST1, a new soldier of NRF2 in the battle against ferroptotic death.
M. Dodson,A. Anandhan,Donna D. Zhang
2021 · DOI: 10.1016/j.chembiol.2021.05.013
Cell Chemical Biology · 25 Citations
TLDR
Microsomal glutathione-S-transferase 1 (MGST1) is identified as an NRF2 target gene that suppresses ferroptosis in pancreatic cancer cells, and could represent a viable therapeutic target for treating pancreatic cancers.
Abstract
In this issue of Cell Chemical Biology, Kuang et al. (2021) identify microsomal glutathione-S-transferase 1 (MGST1) as an NRF2 target gene that suppresses ferroptosis in pancreatic cancer cells. Mechanistically, MGST1 binds ALOX5 during ferroptosis induction, inhibiting lipid peroxide production. Thus, MGST1 could represent a viable therapeutic target for treating pancreatic cancer.