M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy.
M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy.
L. Beck,R. Bonegio,5 Authors,D. Salant
2009 · DOI: 10.1056/NEJMoa0810457
New England Journal of Medicine · 2,107 Citations
TLDR
A majority of patients with idiopathic membranous nephropathy have antibodies against a conformation-dependent epitope in PLA(2)R, indicating that PLA( 2)R is a major antigen in this disease.