Lipase degradation of Dynasan 114 and 116 solid lipid nanoparticles (SLN)--effect of surfactants, storage time and crystallinity.
Lipase degradation of Dynasan 114 and 116 solid lipid nanoparticles (SLN)--effect of surfactants, storage time and crystallinity.
C. Olbrich,O. Kayser,R. Müller
2002 · DOI: 10.1016/S0378-5173(02)00035-2
International journal of pharmaceutics · 171 Citations
TLDR
SLN produced with a higher crystalline lipid in combination with the crystallisation-disturbing NaCh required a 'ripening time' to reach sufficient crystallinity, and showed a decrease in degradation velocity with increasing crystallinity during storage.