Lindane-induced convulsions in NMRI and OF1 mice: antagonism with (+)MK-801 and voltage-dependent calcium channel blockers.
Lindane-induced convulsions in NMRI and OF1 mice: antagonism with (+)MK-801 and voltage-dependent calcium channel blockers.
J. Tusell,M. Vendrell,J. Serratosa,R. Trullás
1992 · DOI: 10.1016/0006-8993(92)91309-3
Brain Research · 32 Citations
TLDR
Nifedipine antagonized lindane-induced seizures with a three-fold higher potency in NMRI than in OF1 mice, suggesting that besides the GABAA receptor complex other mechanisms related to calcium mobilization may be involved in the convulsant action of lINDane.