Lactate sensitive transcription factor network in L6 cells: activation of MCT1 and mitochondrial biogenesis
Lactate sensitive transcription factor network in L6 cells: activation of MCT1 and mitochondrial biogenesis
T. Hashimoto,Rajaa Hussien,2 Authors,George A. Brooks
2007 · DOI: 10.1096/fj.07-8174com
The FASEB Journal · 435 Citations
TLDR
The lactate signaling cascade involves ROS production and converges on transcription factors affecting mi‐tochondrial biogenesis, and concludes that the lactate sensitive transcription factor network in L6 cells: activation of MCT1 and mitochondrial biogenesis.