Krüppel-like factor 9 inhibits glioma cell proliferation and tumorigenicity via downregulation of miR-21.
Krüppel-like factor 9 inhibits glioma cell proliferation and tumorigenicity via downregulation of miR-21.
Shu-yun Huang,Chanjuan Wang,7 Authors,Yiquan Ke
2015 · DOI: 10.1016/j.canlet.2014.10.007
Cancer Letters · 36 Citations
TLDR
It is found that KLF9 expression was strongly reduced in gliomas and interacted with the miR-21 promoter, leading to suppression of mi R-21 expression and cell cycle arrest and taken together, indicates a novel mechanism for KLF function in tumorigenesis.