KNOP1 interacts with NMNAT1 to govern ferroptosis and tumor growth in breast cancer via regulating FoxO1-dependent GPX4 transcription.
KNOP1 interacts with NMNAT1 to govern ferroptosis and tumor growth in breast cancer via regulating FoxO1-dependent GPX4 transcription.
Jingjing Gan,Liang Li,2 Authors,Lingling Li
2025 · DOI: 10.1016/j.cellsig.2025.112049
Cellular Signalling · 0 Citations
TLDR
It is established that the KNOP1/NMNAT1 complex promotes BRCA progression through NAD+-dependent FoxO1/GPX4 signaling to inhibit ferroptosis, suggesting this axis as a novel therapeutic target for BRCA treatment strategies aimed at modulating iron-dependent cell death pathways.