Invasive Shigella flexneri Activates NF-κB Through a Lipopolysaccharide-Dependent Innate Intracellular Response and Leads to IL-8 Expression in Epithelial Cells1
Invasive Shigella flexneri Activates NF-κB Through a Lipopolysaccharide-Dependent Innate Intracellular Response and Leads to IL-8 Expression in Epithelial Cells1
D. Philpott,S. Yamaoka,A. Israël,P. Sansonetti
2000 · DOI: 10.4049/jimmunol.165.2.903
Journal of Immunology · 260 Citations
TLDR
The eukaryotic transcription factor NF-κB was activated during S. flexneri infection of epithelial cells, which suggests a role for this transcriptional regulator in modulating the immune response during infection in vivo.